- Physical and psychiatric comorbidities are common in bipolar disorder (BD), but they may not all be associated with long-term outcomes.
- The risk of manic relapses in BD was increased by thyroid disease, specifically hypothyroidism, and may be specifically modulated by baseline thyroid-stimulating hormone (TSH).
- The detection and treatment of hypothyroidism in BD should be considered a risk factor for manic relapse during the long-term progression of the disorder.
The following is a summary of Amann BL, Radua J, Wunsch C, König B, Simhandl C. Psychiatric and physical comorbidities and their impact on the course of bipolar disorder: a prospective, naturalistic 4-year follow-up study. Bipolar Disord. 2017;19(3):225-234, which was developed independently of the article authors. Background Relapses are frequent in bipolar disorder (BD), so…