Psychiatric & Physical Comorbidities & Their Impact On The Course Of Bipolar Disorder: A Prospective, Naturalistic 4-Year Follow-Up Study

Research Summary | December 11, 2017

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Key Messages

  • Physical and psychiatric comorbidities are common in bipolar disorder (BD), but they may not all be associated with long-term outcomes.
  • The risk of manic relapses in BD was increased by thyroid disease, specifically hypothyroidism, and may be specifically modulated by baseline thyroid-stimulating hormone (TSH).
  • The detection and treatment of hypothyroidism in BD should be considered a risk factor for manic relapse during the long-term progression of the disorder.

The following is a summary of Amann BL, Radua J, Wunsch C, König B, Simhandl C. Psychiatric and physical comorbidities and their impact on the course of bipolar disorder: a prospective, naturalistic 4-year follow-up study. Bipolar Disord. 2017;19(3):225-234, which was developed independently of the article authors. Background Relapses are frequent in bipolar disorder (BD), so…

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