- This collection of complementary nonclinical and clinical studies evaluated the expression of miR-1202, a microRNA (miRNA) specific to primates and enriched in the human brain.
- miR-1202 showed decreased expression in the brains of patients with depression.
- miR-1202 expression was inversely associated with expression of the metabotropic glutamate receptor 4 (GRM4) gene – a gene that modulates dopaminergic, glutamatergic, and serotonergic neurotransmission.
- Chronic exposure to antidepressants reduced GRM4 mRNA expression in a preclinical study.
- Response to antidepressants resulted in increased miR-1202 expression.
The following is a summary of Lopez JP, et al. miR-1202: A primate specific and brain enriched miRNA involved in major depression and antidepressant treatment. Nat Med 2014;20(7):764-68, which was developed independently of the article authors. Background Major depressive disorder (MDD) is associated with the differential expression of various biomarkers in the brain. Multiple lines…