miR-1202: A Primate-Specific & Brain-Enriched miRNA Involved In Major Depression & Antidepressant Treatment

Research Summary | April 19, 2017

Not A Member? Sign up for free.

Join us as we continue our efforts towards improving the future of mental health care through information, discussion, and collaboration. Sign-up today for instant access to all PsychU offerings. Membership is free!

Key Messages

  • This collection of complementary nonclinical and clinical studies evaluated the expression of miR-1202, a microRNA (miRNA) specific to primates and enriched in the human brain.
  • miR-1202 showed decreased expression in the brains of patients with depression.
  • miR-1202 expression was inversely associated with expression of the metabotropic glutamate receptor 4 (GRM4) gene – a gene that modulates dopaminergic, glutamatergic, and serotonergic neurotransmission.
  • Chronic exposure to antidepressants reduced GRM4 mRNA expression in a preclinical study.
  • Response to antidepressants resulted in increased miR-1202 expression.

The following is a summary of Lopez JP, et al. miR-1202: A primate specific and brain enriched miRNA involved in major depression and antidepressant treatment. Nat Med 2014;20(7):764-68, which was developed independently of the article authors. Background Major depressive disorder (MDD) is associated with the differential expression of various biomarkers in the brain. Multiple lines…

You must be logged in to read the full article: Join or Log In

Similar Articles