- Patients with bipolar I disorder (BD I) who experienced recurring mood episodes demonstrated decreases in gray matter volume (GMV) in certain brain regions known to regulate emotion.
- Changes in GMV in patients with BD I who were in remission 1 year after their first manic episode were not significantly different from GMV changes in healthy subjects, suggesting that early interventions designed to prevent mood episodes may minimize neuroprogression of BD I.
The following is a summary of Kozicky J-M, McGirr A, Bond DJ, Gonzalez M, Silveira LE, Keramatian K, Torres IJ, Lam RW, Yatham LN. Neuroprogression and episode recurrence in bipolar I disorder: a study of gray matter volume changes in first-episode mania and association with clinical outcome. Bipolar Disord. 2016;18(6):511-519, which was developed independently of…