Neuroinflammation & White Matter Pathology In Schizophrenia: Systematic Review
Key Messages
White matter (WM) pathology and neuroinflammation have each been associated with schizophrenia in separate lines of research. This systematic literature review examined whether a relationship exists between WM pathology and neuroinflammation in schizophrenia.
Based on 15 neuropathological and neuroimaging studies involving 792 subjects, the authors concluded that neuroinflammation is associated with WM pathology in schizophrenia. Key findings included:
Schizophrenia is associated with microglial activation and proliferation, particularly in WM.
Pro-inflammatory cytokine genetic mutations and mRNA expression levels are associated with reduced WM …
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