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Glial Abnormalities In Substance Use Disorders & Depression: Does Shared Glutamatergic Dysfunction Contribute To Comorbidity?

Research Summary | February 24, 2017

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Key Messages Substance use disorders (SUDs) and depression frequently co-occur. In order to identify glial cell-associated pathophysiology shared by these disorders, studies of astrocyte, microglia, and oligodendrocyte dysfunction in SUDs and depression were reviewed. Glial-associated abnormalities observed in both SUDs and depression included reduced numbers of astrocytes, changes in astrocyte neurotrophin production, and altered glutamate…

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