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Bipolar Spectrum Disorder Or Unique Subtype Of Depression? Defining Characteristics Of Treatment-Resistant Unipolar Depression

Research Summary | November 5, 2018

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Background & Purpose Although there is currently no universal definition for treatment-resistant unipolar depression (TRD-UP), some have described it as either the failure to respond to the first antidepressant (AD) trial or to two or more trials of different classes of AD. Given the controversy, prevalence rates and treatment outcomes remain ambiguous, though it is…

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